Phenotypes Associated with This Genotype

Genotype
MGI:6195748

• Allelic Composition: Gt(ROSA)26Sor^{tm18(Zeb2)Jhai}/Gt(ROSA)26Sor⁺; Tg(Tek-cre)1Ywa/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:263520 )

• mice develop tumors after 15.5 weeks of age, with a complete shift towards hematopoietic neoplastic lesions (100%), mainly precursor T-cell lymphoma (85.7%)

• T-cell antigen receptor rearrangement analysis suggests either mono- or oligoclonal origin for all the thymic tumors

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:263520 )

• mice develop tumors after 15.5 weeks of age, with a complete shift towards hematopoietic neoplastic lesions (100%), mainly precursor T-cell lymphoma (85.7%)

• T-cell antigen receptor rearrangement analysis suggests either mono- or oligoclonal origin for all the thymic tumors

hematopoietic system

increased T cell derived lymphoma incidence ( J:263520 )

• mice develop tumors after 15.5 weeks of age, with a complete shift towards hematopoietic neoplastic lesions (100%), mainly precursor T-cell lymphoma (85.7%)

• T-cell antigen receptor rearrangement analysis suggests either mono- or oligoclonal origin for all the thymic tumors

immune system

increased T cell derived lymphoma incidence ( J:263520 )

• mice develop tumors after 15.5 weeks of age, with a complete shift towards hematopoietic neoplastic lesions (100%), mainly precursor T-cell lymphoma (85.7%)

• T-cell antigen receptor rearrangement analysis suggests either mono- or oligoclonal origin for all the thymic tumors