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Phenotypes Associated with This Genotype
Genotype
MGI:6189103
Allelic
Composition
Chd8tm2.1Kei/Chd8+
Genetic
Background
B6J.129P2-Chd8tm2.1Kei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd8tm2.1Kei mutation (1 available); any Chd8 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the T-maze left-right discrimination test, mice show reduced percentage of correct responses after directional reversal compared to controls, suggesting that mice exhibit increased persistence
• however, mice show normal memory in the T-maze forced-alternation test
• mice spend less time in the light chamber for the light-dark transition test, in the open arms for the elevated plus-maze test, and in the center of the open-field indicating increased anxiety
• mice show a lower acoustic startle response
• mice show reduced number of social contacts in the social-interaction test but an increase in the duration per contact, resulting in an increase in total contact time
• however, the total duration of active contacts such as sniffing and following behavior is reduced
• mice show a reduction in contact time between familiar and stranger mice in the sociability and social-novelty preference test

digestive/alimentary system
• mice have shorter intestine
• mice tend to show slower intestinal transit

growth/size/body
• brain weight and volume are increased indicating macrocephaly

nervous system
• brain weight at E18.5 and in adulthood is increased
• expression analysis indicates a delay in neurodevelopment in fetal stages
• mice exhibit increased prepulse inhibition for 74- or 78-dB prepulses before a 120-dB startle stimulus

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:235128


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory