Phenotypes Associated with This Genotype

Genotype
MGI:6188029

• Allelic Composition: Tg(Thy1-EGFP/RNAi:Sumo3/RNAi:Sumo2/RNAi:Sumo1)27Weiy/?
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:260337 )

impaired cued conditioning behavior ( J:260337 )

abnormal habituation to a novel object ( J:260337 )

• novel object preferences are reduced for the short term and long term memory tests, however, mice spend more time exploring and interacting with objects

increased anxiety-related response ( J:260337 )

• mice spend less time in center zone and more time in corners

• activity in periphery is increased

abnormal fear-related response ( J:260337 )

• impaired fear-potentiated startle response

nervous system

decreased dendritic spine density ( J:260337 )

• synaptic spine density is reduced in CA1 neurons, but not in basolateral amygdala neurons