Phenotypes Associated with This Genotype

Genotype
MGI:6163840

• Allelic Composition: Pole4^{tm1(KOMP)Vlcg}/Pole4^{tm1(KOMP)Vlcg}; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:261973 )

• unlike single Pole4^{tm1(KOMP)Vlcg} homozygotes, which are essentially embryonic lethal in the inbred C57BL/6 background, double-mutant mice are born at sub-Mendelian ratios (3.7% born versus 6.25% expected)

behavior/neurological

impaired coordination ( J:261973 )

• loss of rotarod coordination, observed in single Pole4^{tm1(KOMP)Vlcg} homozygotes, is only partially rescued by deleting both Trp53 alleles

growth/size/body

growth/size/body region phenotype ( J:261973 )

N • double-mutant mice lack gross abnormalities and exhibit a size similar to that of single Trp53^tm1Brd homozygotes

immune system

immune system phenotype ( J:261973 )

N • double-mutant mice exhibit rescue of the absolute number and proportion of white blood cells; the numbers of T cells (CD4+ and CD8+) and B cells are restored to levels comparable to those in single Trp53^tm1Brd homozygotes