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Phenotypes Associated with This Genotype
Genotype
MGI:6163840
Allelic
Composition
Pole4tm1(KOMP)Vlcg/Pole4tm1(KOMP)Vlcg
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background
involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pole4tm1(KOMP)Vlcg mutation (0 available); any Pole4 mutation (4 available)
Trp53tm1Brd mutation (7 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• unlike single Pole4tm1(KOMP)Vlcg homozygotes, which are essentially embryonic lethal in the inbred C57BL/6 background, double-mutant mice are born at sub-Mendelian ratios (3.7% born versus 6.25% expected)

behavior/neurological
• loss of rotarod coordination, observed in single Pole4tm1(KOMP)Vlcg homozygotes, is only partially rescued by deleting both Trp53 alleles

growth/size/body
N
• double-mutant mice lack gross abnormalities and exhibit a size similar to that of single Trp53tm1Brd homozygotes

immune system
N
• double-mutant mice exhibit rescue of the absolute number and proportion of white blood cells; the numbers of T cells (CD4+ and CD8+) and B cells are restored to levels comparable to those in single Trp53tm1Brd homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory