Phenotypes Associated with This Genotype

Genotype
MGI:6163825

• Allelic Composition: Pole4^{tm1(KOMP)Vlcg}/Pole4^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:261973 )

• most embryos die between E11.5 and E13.5

• only 1 viable mouse is obtained out of 63 expected

embryo

abnormal embryo development ( J:261973 )

• most embryos die with extensive developmental defects

cellular

abnormal DNA replication ( J:261973 )

• mouse embryonic fibroblasts (MEFs) derived from severely affected embryos in a C57BL/6 inbred background show significantly higher replication fork extension rates than wild-type MEFs

homeostasis/metabolism

abnormal DNA replication ( J:261973 )

• mouse embryonic fibroblasts (MEFs) derived from severely affected embryos in a C57BL/6 inbred background show significantly higher replication fork extension rates than wild-type MEFs