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Phenotypes Associated with This Genotype
Genotype
MGI:6163825
Allelic
Composition
Pole4tm1(KOMP)Vlcg/Pole4tm1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pole4tm1(KOMP)Vlcg mutation (0 available); any Pole4 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most embryos die between E11.5 and E13.5
• only 1 viable mouse is obtained out of 63 expected

embryo
• most embryos die with extensive developmental defects

cellular
• mouse embryonic fibroblasts (MEFs) derived from severely affected embryos in a C57BL/6 inbred background show significantly higher replication fork extension rates than wild-type MEFs

homeostasis/metabolism
• mouse embryonic fibroblasts (MEFs) derived from severely affected embryos in a C57BL/6 inbred background show significantly higher replication fork extension rates than wild-type MEFs


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory