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Phenotypes Associated with This Genotype
Genotype
MGI:6160055
Allelic
Composition
Ecel1tm1Hiki/Ecel1tm1Hiki
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ecel1tm1Hiki mutation (0 available); any Ecel1 mutation (23 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• while most motor nerves reach muscles, their fine branches are poorly arborized
• in the hip, thigh, and lower leg, the number of motor nerve terminals is reduced to over half of the muscles and is dramatically reduced in the lateral, middle, and medial muscles of the foot
• however, the width of motor nerves (the gracilis motor nerve) and the number of individual axons within motor nerves are normal
• motor nerves exhibit impaired axonal arborization in skeletal muscles in the forelimbs and hindlimbs, first seen around E12.5-E13.5
• axonal arborization defect in foot muscles is more severe than in other hindlimb muscles, with almost all fine branches absent in the E17.5 lateral, medial and medial muscles of the foot
• axonal arborization defects are more severe at the most distal part of the limb compared with proximal regions
• however, motor nerves exhibit normal trajectory patterns from the spinal cord to skeletal muscles and motor nerves develop a normal number of fine branches in some muscles such as vastus lateralis and biceps femoris
• early phase of axonal outgrowth is not affected
• the number of neuromuscular junctions is reduced in the gracilis anterior muscle
• number of innervated neuromuscular junctions is reduced in severely affected muscle


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory