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Phenotypes Associated with This Genotype
Genotype
MGI:6159280
Allelic
Composition		 Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi
Tg(ACTA1-cre/Esr1*)2Kesr/0
Genetic
Background		 involves: C3H * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam210atm1c(EUCOMM)Wtsi mutation (1 available); any Fam210a mutation (19 available)
Tg(ACTA1-cre/Esr1*)2Kesr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
increased osteoclast cell number ( J:261817 )
• in tamoxifen-treated mice
decreased bone mineral density ( J:261817 )
• in tamoxifen-treated male mice

behavior/neurological
decreased grip strength ( J:261817 )
• in tamoxifen-treated mice

limbs/digits/tail
abnormal limb morphology ( J:261817 )
• decreased lean muscle mass in all limbs of tamoxifen-treated mice

growth/size/body
growth/size/body region phenotype ( J:261817 )
N
• tamoxifen-treated mice exhibit normal body weight

immune system
increased osteoclast cell number ( J:261817 )
• in tamoxifen-treated mice

hematopoietic system
increased osteoclast cell number ( J:261817 )
• in tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory