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Phenotypes Associated with This Genotype
Genotype
MGI:6150431
Allelic
Composition
Zfp106tm1b(KOMP)Wtsi/Zfp106tm1b(KOMP)Wtsi
Genetic
Background
involves: C57BL/6N
Cell Lines EPD0033_4_C03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp106tm1b(KOMP)Wtsi mutation (0 available); any Zfp106 mutation (93 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• in quadriceps muscles
• increased variation in fiber size
• very few centrally located nuclei
• grouped atrophy in quadriceps muscles
• extensive, at 3 months of age
• severe, at 3 months of age

behavior/neurological
• reduced muscle strength from 4 weeks of age in all mice

nervous system
• significantly reduced number of choline-acetyltransferase-positive motor neurons in spinal cord

growth/size/body
• due to muscle wasting

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis DOID:332 OMIM:PS105400
J:241305


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory