Phenotypes for Amotl2 Tg(Cdh5-cre/ERT2)1Rha MGI:6121065 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Amotl2^tm1.1Laho/Amotl2^tm1.1Laho Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl2^tm1.1Laho mutation (0 available); any Amotl2 mutation (54 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:226656 )

N	• postnatal retinal angiogenesis

abnormal aorta morphology ( J:226656 )

• embryo aortic endothelial cells shaped short and rounded

aorta stenosis ( J:226656 )

• in 80% of E9.5 embryos

abnormal vascular endothelial cell morphology ( J:226656 )

• embryo aortic endothelial cells shaped short and rounded

• endothelium of embryo posterior cardinal vein (PCV), intersegmental vessels (ISVs) and brain vascular plexus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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