About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6120521
Allelic
Composition
Myo9atm1.2Bah/Myo9atm1.2Bah
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo9atm1.2Bah mutation (0 available); any Myo9a mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• hopping and trembling

embryo
• disorganized ependymal cells lining ventral caudal 3rd ventricle
• absent ependymal cells lining ventral caudal 3rd ventricle in areas of ventricle closure
• undulated appearance: distorted overall outline of ependymal cells marked by adherens junctions, with bent and strained cell-cell boundaries, first observed at P0.5
• single layer of ependymal cells transformed into multilayer configuration at multiple sites
• disordered mature ependymal epithelial cells form amorphous accumulations of cells obstructing ventricular passage
• significant reduction in number of mature multiciliated ependymal cells in ventral caudal 3rd ventricle

growth/size/body

nervous system
N
• subarachnoid space and 4th ventricle morphology
• disorganized ependymal cells lining ventral caudal 3rd ventricle
• absent ependymal cells lining ventral caudal 3rd ventricle in areas of ventricle closure
• undulated appearance: distorted overall outline of ependymal cells marked by adherens junctions, with bent and strained cell-cell boundaries, first observed at P0.5
• single layer of ependymal cells transformed into multilayer configuration at multiple sites
• disordered mature ependymal epithelial cells form amorphous accumulations of cells obstructing ventricular passage
• significant reduction in number of mature multiciliated ependymal cells in ventral caudal 3rd ventricle
• highly dilated
• distorted and closed ventral caudal 3rd ventricle
• highly dilated rostral to closed region of aqueduct
• at ventral caudal 3rd ventricle
• disordered mature ependymal epithelial cells form amorphous accumulations of cells obstructing ventricular passage
• generally asymmetric and distorted bilobed canal at dorsal side of rostral aqueduct
• partially closed, forming two separate small lumens lined by ependymal epithelial cells
• discontinuities with denudations of ependymal epithelial layer in median aqueduct, especially in vaults
• undulated appearance: distorted overall outline of ependymal cells marked by adherens junctions, with bent and strained cell-cell boundaries, first observed at P0.5
• single layer of ependymal cells transformed into multilayer configuration at multiple sites
• becomes progressively narrower and ultimately closes (stenosis) between P0.5 and P14.5
• significant reduction in number of mature multiciliated ependymal cells in rostral aqueduct

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
obstructive hydrocephalus DOID:14159 J:251454


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/13/2019
MGI 6.14
The Jackson Laboratory