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Phenotypes Associated with This Genotype
Genotype
MGI:6119480
Allelic
Composition
Tubb5tm1.1Dak/Tubb5tm1.1Dak
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Tubb5tm1.1Dak mutation (0 available); any Tubb5 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• with reduced cortex volume
• reduced volume
• reduced volume
• reduced volume
• at P0 and severely reduced in adulthood
• however, cortex thickness is normal at E12.5, E14.5 and E16.5
• reduced volume
• loss of upper neuronal layer
• however, cortical architecture is preserved
• reduced volume
• ectopic neuronal progenitors with an increased percentage of vertically oriented spindles at E14.5

cellular
• prolonged M phase in neuronal progenitors at E14.5 with abnormal chromosome elements
• increased percentage of vertically oriented spindles in neuronal progenitors at E14.5

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microcephaly DOID:10907 J:240157


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory