Phenotypes Associated with This Genotype

Genotype
MGI:6118934

• Allelic Composition: Pgrmc1^tm1.1Jjp/Pgrmc1^tm1.1Jjp; Pgrmc2^tm1.1Jjp/Pgrmc2^tm1.1Jjp; Pgr^tm2(cre)Lyd/Pgr⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

early reproductive senescence ( J:247103 )

♀ • in female mice

reproductive system

uterus cyst ( J:247103 )

♀ • in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months

early reproductive senescence ( J:247103 )

♀ • in female mice

abnormal endometrium morphology ( J:247103 )

♀ • breakdown of basement membrane and disruption of epithelial-stromal interface

abnormal endometrial gland morphology ( J:247103 )

♀ • vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells

increased endometrial gland number ( J:247103 )

♀

enlarged endometrial glands ( J:247103 )

♀ • enlarged amorphic and cystic glands characteristic of aged endometrium

reduced female fertility ( J:247103 )

♀ • female mice have fewer pups per litter and fewer litters per female compared with control mice

decreased litter size ( J:247103 )

♀ • fewer pups per litter and fewer litters per female

endocrine/exocrine glands

abnormal endometrial gland morphology ( J:247103 )

♀ • vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells

increased endometrial gland number ( J:247103 )

♀

enlarged endometrial glands ( J:247103 )

♀ • enlarged amorphic and cystic glands characteristic of aged endometrium

growth/size/body

uterus cyst ( J:247103 )

♀ • in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months