Analysis Tools
mortality/aging
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• 50% of female mice become infertile after the third parity
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reproductive system
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• at 6 days of pregnancy
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uterus cyst
(
J:247103
)
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• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months
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• 50% of female mice become infertile after the third parity
|
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• breakdown of basement membrane and disruption of epithelial-stromal interface
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• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
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• enlarged amorphic and cystic glands characteristic of aged endometrium
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• despite normal ovulation, female mice have fewer pups per litter and fewer litters per female compared with control mice
• however, weanling weights are normal
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• fewer pups per litter and fewer litters per female
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homeostasis/metabolism
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• marginally at 10.5 days of pregnancy
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embryo
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• at 6 days of pregnancy
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immune system
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• at 6 days of pregnancy
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endocrine/exocrine glands
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• at 6 days of pregnancy
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• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
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• enlarged amorphic and cystic glands characteristic of aged endometrium
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hematopoietic system
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• at 6 days of pregnancy
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growth/size/body
uterus cyst
(
J:247103
)
|
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• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months
|
