Phenotypes Associated with This Genotype

Genotype
MGI:6116651

• Allelic Composition: Myo10^{tm1a(KOMP)Wtsi}/Myo10^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0332_3_B02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:256438 )

• only 45% of homozygotes survived birth and grew to adulthood

lethality during fetal growth through weaning, incomplete penetrance ( J:256438 )

• homozygous mutant pups from heterozygous matings were obtained at less than half (45%) the expected number, suggesting a high frequency of embryonic or perinatal lethality

nervous system

exencephaly ( J:256438 )

• at E12.5, 9 of 18 (50%) embryos resulting from 2 homozygous crosses exhibited exencephaly

vision/eye

persistence of hyaloid vascular system ( J:256438 )

• all adult homozygotes whose eyes were dissected (5 of 5) had persistent hyaloid vasculature that was pigmented and bilateral

pigmentation

white spotting ( J:256438 )

• all surviving homozygotes had a white belly spot; a few also had a white spot on the back

belly spot ( J:256438 )

• all surviving homozygotes had a white belly spot

limbs/digits/tail

syndactyly ( J:256438 )

• ~50% of adult homozygotes had webbed digits, usually on the forelimbs

kinked tail ( J:256438 )

• ~50% of adult homozygotes had a kink near the tip of the tail

integument

white spotting ( J:256438 )

• all surviving homozygotes had a white belly spot; a few also had a white spot on the back

belly spot ( J:256438 )

• all surviving homozygotes had a white belly spot