Phenotypes Associated with This Genotype

Genotype
MGI:6115875

• Allelic Composition: Setd2^{tm1c(NCOM)Mfgc}/Setd2^{tm1c(NCOM)Mfgc}; Tg(Lck-cre)#Zhu/0
• Genetic Background: involves: C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:243973 )

N • alpha-beta T cell number

increased gamma-delta T cell number ( J:243973 )

• increase in gamma-delta to alpha-beta CD3e+ intraepithelial T cells ratio to 2.2 (from 1.4 in wild-type)

• increase in percentage gamma-delta CD3e+ T cells in epithelium

• increase in gamma-delta to alpha-beta Peyers patch T cells ratio

• increase in percentage gamma-delta T cells in Peyers patch

• gamma-delta to alpha-beta Peyers patch and intraepithelial CD8alpha+ T cells ratio

immune system

increased gamma-delta T cell number ( J:243973 )

• increase in gamma-delta to alpha-beta CD3e+ intraepithelial T cells ratio to 2.2 (from 1.4 in wild-type)

• increase in percentage gamma-delta CD3e+ T cells in epithelium

• increase in gamma-delta to alpha-beta Peyers patch T cells ratio

• increase in percentage gamma-delta T cells in Peyers patch

• gamma-delta to alpha-beta Peyers patch and intraepithelial CD8alpha+ T cells ratio

neoplasm

neoplasm ( J:243973 )

N • no lymphoma development after 10 months of age