Phenotypes Associated with This Genotype

Genotype
MGI:6115777

• Allelic Composition: Ndst4^tm1.1Ntuy/Ndst4^tm1.1Ntuy
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased enterocyte apoptosis ( J:252046 )

• at 10-11 weeks of age, mice show a significantly increased level of apoptosis of colonic epithelial cells in the proximal colon relative to wild-type controls

abnormal intestinal epithelium morphology ( J:252046 )

• at 10-11 weeks of age, mice exhibit altered cell lineage differentiation of the colonic epithelium

abnormal colon morphology ( J:252046 )

• at 10-11 weeks of age, colonocyte number is significantly decreased in the proximal colon relative to that in wild-type controls

• however, colonic crypt length and colonic epithelium proliferation are normal

increased colon goblet cell number ( J:252046 )

• at 10-11 weeks of age, the number of mucus-secreting goblet cells is significantly increased in the proximal colonic mucosa relative to that in wild-type controls

cellular

increased colon goblet cell number ( J:252046 )

• at 10-11 weeks of age, the number of mucus-secreting goblet cells is significantly increased in the proximal colonic mucosa relative to that in wild-type controls

increased enterocyte apoptosis ( J:252046 )

• at 10-11 weeks of age, mice show a significantly increased level of apoptosis of colonic epithelial cells in the proximal colon relative to wild-type controls

endocrine/exocrine glands

increased colon goblet cell number ( J:252046 )

• at 10-11 weeks of age, the number of mucus-secreting goblet cells is significantly increased in the proximal colonic mucosa relative to that in wild-type controls