Phenotypes Associated with This Genotype

Genotype
MGI:6113948

• Allelic Composition: Sox17^tm2Sjm/Sox17⁺; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal cystic duct morphology ( J:241569 )

• embryos show varying degrees of shortening of the cystic duct

biliary atresia ( J:241569 )

• embryos exhibit biliary atresia-like phenotypes such as epithelial deciduation and bile duct stenosis/atresia

abnormal gallbladder epithelium morphology ( J:241569 )

• epithelial deciduation in the gallbladder

abnormal gallbladder size ( J:241569 )

• embryos show varying degrees of shortening of the gallbladder

immune system

liver inflammation ( J:241569 )

• hepatitis in fetuses with normal or mild gallbladder abnormalities but not hepatitis in fetuses with complete lack of the gallbladder

liver/biliary system

abnormal cystic duct morphology ( J:241569 )

• embryos show varying degrees of shortening of the cystic duct

biliary atresia ( J:241569 )

• embryos exhibit biliary atresia-like phenotypes such as epithelial deciduation and bile duct stenosis/atresia

abnormal gallbladder epithelium morphology ( J:241569 )

• epithelial deciduation in the gallbladder

abnormal gallbladder size ( J:241569 )

• embryos show varying degrees of shortening of the gallbladder

liver inflammation ( J:241569 )

• hepatitis in fetuses with normal or mild gallbladder abnormalities but not hepatitis in fetuses with complete lack of the gallbladder

abnormal liver morphology ( J:241569 )

• 4/55 embryos exhibit severe gross hepatic lesions

cholestasis ( J:241569 )

• bile duct stenosis