Phenotypes for Park7 Pink1 Rrn3 Tg(Slc6a3-cre/ERT2)1Span MGI:6113544 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Park7^Gt(XE726)Byg/Park7^Gt(XE726)Byg Pink1^tm1.1Wrst/Pink1^tm1.1Wrst Rrn3^tm1.1Igt/Rrn3^tm1.1Igt Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background	involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7^Gt(XE726)Byg mutation (1 available); any Park7 mutation (56 available)
Pink1^tm1.1Wrst mutation (0 available); any Pink1 mutation (43 available)
Rrn3^tm1.1Igt mutation (3 available); any Rrn3 mutation (41 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal nucleolus morphology ( J:242309 )

• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants

abnormal cell physiology ( J:242309 )

• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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