Phenotypes Associated with This Genotype

Genotype
MGI:6112615

• Allelic Composition: Irf4^tm1Rdf/Irf4^tm1Rdf; Tg(Ucp1-cre)1Evdr/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal adipose tissue development ( J:214637 )

• reduced lipogenesis in isopropetenol-treated adipocytes

increased body fat mass ( J:214637 )

• small increased when fed standard chow

• elevated when fed a high-fat diet

increased white fat cell size ( J:214637 )

• in inguinal and epididymal fat pads with increased lipid content

increased epididymal fat pad weight ( J:214637 )

increased inguinal fat pad weight ( J:214637 )

homeostasis/metabolism

decreased fatty acid oxidation ( J:214637 )

impaired adaptive thermogenesis ( J:214637 )

• in cold-exposed mice

decreased core body temperature ( J:214637 )

• in cold-exposed mice

decreased carbon dioxide production ( J:214637 )

decreased oxygen consumption ( J:214637 )

impaired glucose tolerance ( J:214637 )

• when fed a high-fat diet

insulin resistance ( J:214637 )

• when fed a high-fat diet

impaired lipolysis ( J:214637 )

• when mice are fed standard chow

growth/size/body

increased body fat mass ( J:214637 )

• small increased when fed standard chow

• elevated when fed a high-fat diet

increased body weight ( J:214637 )

• when fed a high-fat diet despite normal food intake

cellular

abnormal cellular respiration ( J:214637 )

• reduced in the mitochondria of brown adipocytes despite normal mitochondrial number and cristae density

decreased fatty acid oxidation ( J:214637 )