Phenotypes Associated with This Genotype

Genotype
MGI:6110829

• Allelic Composition: Sclt1^{Tg(CAG-sb10)1Dla}/Sclt1^{Tg(CAG-sb10)1Dla}
• Genetic Background: FVB/N-Sclt1^{Tg(CAG-sb10)1Dla}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney morphology ( J:243427 )

• paler kidneys by P8

kidney medulla cyst ( J:243427 )

• cysts originate from both collecting and proximal tubule

polycystic kidney ( J:243427 )

• decreased cellularity in cyst-lining epithelium by P21

enlarged kidney ( J:243427 )

• moderately larger kidneys by P8

• 3-fold larger kidneys by P21

renal fibrosis ( J:243427 )

growth/size/body

growth/size/body region phenotype ( J:243427 )

N • body weight

cleft palate ( J:243427 )

• increased frequency

slow postnatal weight gain ( J:243427 )

• growth retardation by P8

cachexia ( J:243427 )

kidney medulla cyst ( J:243427 )

• cysts originate from both collecting and proximal tubule

polycystic kidney ( J:243427 )

• decreased cellularity in cyst-lining epithelium by P21

enlarged kidney ( J:243427 )

• moderately larger kidneys by P8

• 3-fold larger kidneys by P21

digestive/alimentary system

cleft palate ( J:243427 )

• increased frequency

decreased intestine length ( J:243427 )

homeostasis/metabolism

increased blood urea nitrogen level ( J:243427 )

limbs/digits/tail

preaxial polydactyly ( J:243427 )

• in hind limbs

mortality/aging

premature death ( J:243427 )

• pups die before age 1 month

craniofacial

cleft palate ( J:243427 )

• increased frequency

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861	OMIM:263200	J:243427
ciliopathy		DOID:0060340		J:243427