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Phenotypes Associated with This Genotype
Genotype
MGI:6105946
Allelic
Composition		 Cd8atm1Mak/Cd8atm1Mak
Il15tm1Imx/Il15tm1Imx
X/Yaa
Genetic
Background		 BXSB.Cg-Cd8atm1Mak Il15tm1Imx/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Mak mutation (7 available); any Cd8a mutation (40 available)
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Yaa mutation (23 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
renal glomerular immunoglobulin deposits ( J:179430 )
• glomerular deposition of IgG at 14 weeks of age is more severe than that of BXSB/MpJ males

immune system
increased monocyte cell number ( J:179430 )
• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
abnormal spleen B cell follicle morphology ( J:179430 )
• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
increased splenocyte number ( J:179430 )
• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
increased IgG1 level ( J:179430 )
• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased IgG2a level ( J:179430 )
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased IgG2b level ( J:179430 )
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased susceptibility to systemic lupus erythematosus ( J:179430 )
• while BXSB/MpJ males develop SLE-like disease and have a mean survival of 32 weeks, males homozygous for both null alleles die earlier than those with just one null allele and with a survival curve essentially the same as that of beta 2 microglobulin null Yaa carrying males, with a mean survival of only 18 weeks
increased anti-nuclear antigen antibody level ( J:179430 )
• elevated over BXSB/MpJ males at 6 and 14 weeks of age

hematopoietic system
increased monocyte cell number ( J:179430 )
• at 14 weeks of age relative to BSXB/MpJ or BXSB.B6=Yaa+ males
abnormal spleen B cell follicle morphology ( J:179430 )
• scattered follicular distribution in the spleen and large extrafollicular accumulations of CD138+ plasma cells and plasmablasts are found at 14 weeks of age
increased splenocyte number ( J:179430 )
• by 14 weeks of age compared with BXSB/MpJ males and the splenocytes have an increased proportion of monocytes, increased ICOS expression on CD4+ T cells, and increased FAS expression on B cells
increased IgG1 level ( J:179430 )
• significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased IgG2a level ( J:179430 )
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed
increased IgG2b level ( J:179430 )
• elevated earlier and significantly higher than BXSB/MpJ males as early as 4 weeks of age, the earliest timepoint assessed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory