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Phenotypes Associated with This Genotype
Genotype
MGI:6104236
Allelic
Composition		 Cd8atm1Mak/Cd8atm1Mak
X/Yaa
Genetic
Background		 BXSB.129S2(B6)-Cd8atm1Mak/4Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Mak mutation (7 available); any Cd8a mutation (39 available)
Yaa mutation (23 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to systemic lupus erythematosus ( J:179430 )
• compared with BXSB/MpJ males that carry Yaa, the additional ablation of CD8A accelerates the mortality from the spontaneous lupus erythematosus-like syndrome such that mortality occurs as early as 12 to 15 weeks of age and mean survival is only 20 weeks of age

mortality/aging

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory