Analysis Tools
muscle
mortality/aging
|
• by 14 weeks in severely affected mice
|
homeostasis/metabolism
| N |
• surviving mice exhibit normal food intake, energy expenditure and respiratory ratio at ambient or cold temperatures
• mice exhibit normal T4 levels
|
|
• in the muscle of mice fed a high-fat diet
|
|
• in response to cold exposure on a high fat diet, mice exhibit reduced body temperature and a 3-fold increase in energy expenditure compared with control mice
|
hypoglycemia
(
J:159612
)
|
• under basal fed conditions
|
|
• under basal fed conditions
|
|
• at 3 months in surviving mice
• however, adiponectin levels are normal
|
|
• increased norephinephrine excretion
|
|
• 3-fold in response to cold exposure on a high fat diet
|
|
• when fed a high-fat diet
|
adipose tissue
|
• almost completely absent in severely affected mice
|
|
• at 3 months in surviving mice
• however, no macrophage infiltration is observed
|
|
• embryonic cells exhibit reduced adipogenesis compared with control cells
|
|
• at 3 months in surviving mice
• however, weights of brown adipose tissue, liver, kidney and heart are normal
|
|
• in epididymal WAT
|
|
• almost completely absent in severely affected mice
|
|
• almost completely absent in severely affected mice
|
|
• almost completely absent in severely affected mice
|
|
• almost completely absent in severely affected mice
|
|
• isoproterenol-treated white adipose tissue adipocytes exhibit reduced lipolytic response compared with control cells
|
growth/size/body
|
• at 3 months in surviving mice
• however, weights of brown adipose tissue, liver, kidney and heart are normal
|
|
• at 3 months in surviving mice
|
|
• when fed a high-fat diet
|
|
• in severely affected mice
|
|
• at 3 months in surviving mice
• however, weights of brown adipose tissue, liver, kidney and heart are normal
|
|
• at 3 months in surviving mice
|
behavior/neurological
|
• in cold-exposed mice
|
liver/biliary system
renal/urinary system
|
• increased norephinephrine excretion
|
integument
|
• almost completely absent in severely affected mice
|
cellular
|
• in the muscle of mice fed a high-fat diet
|
