Phenotypes Associated with This Genotype

Genotype
MGI:6102916

• Allelic Composition: Cebpb^tm1Vpo/Cebpb^tm1Vpo
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired adaptive thermogenesis ( J:117502 )

• inability to maintain body temperature when subjected to cold

increased circulating glucose level ( J:117502 )

• when subjected to cold

increased circulating triglyceride level ( J:117502 )

• when subjected to cold

decreased triglyceride level ( J:117502 )

• in brown adipose tissue

decreased lipoprotein lipase activity ( J:117502 )

• in the brown adipose tissue (basal and cold-induced)

adipose tissue

decreased brown adipose tissue amount ( J:117502 )

• even when expressed relative to body mass

decreased epididymal fat pad weight ( J:117502 )

abnormal brown adipose tissue physiology ( J:117502 )

• brown adipose tissue mitochondria exhibit decreased respiratory capacity compared with wild-type cells

• in cold-exposed mice, brown adipose tissue exhibit reduced triacylglycerol store mobilization and lipoprotein lipase activity compared with wild-type mice

growth/size/body

decreased body weight ( J:117502 )