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Phenotypes Associated with This Genotype
Genotype
MGI:6101467
Allelic
Composition
Fustm1.1Emcf/Fus+
Genetic
Background
involves: C3H * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fustm1.1Emcf mutation (1 available); any Fus mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• modest reduction in survival at 22 months

nervous system
• at 12 and 18 months, but not 3 months
• in aging mice without protein aggregates
• reduced motor units in the extensor digitorum at 18 months
• reduced number of intact neuromuscular junctions at 18 months in hindlimb lumbrical muscles
• however, motor neurons are normal at 3 months
• reduced number of intact neuromuscular junctions at 18 months in hindlimb lumbrical muscles

behavior/neurological
• at 12 and 15 months, mice exhibit hindlimb locotronic errors
• altered rear stride at 18 months with reduction in the time the rear limb is in the swing phase
• however, stride length is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 6 DOID:0060198 OMIM:608030
J:249965


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory