Phenotypes Associated with This Genotype

Genotype
MGI:6100917

• Allelic Composition: Cmtm7^{tm2a(EUCOMM)Hmgu}/Cmtm7⁺; Rag1^tm1Fwa/Rag1^tm1Fwa
• Genetic Background: chimera involves: C57BL/6 * C57BL/6N
• Cell Lines: HEPD0787_6_G03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased plasma cell number ( J:207033 )

• greatly reduced frequency of IgM-secreting plasma cells

abnormal B-1a B cell morphology ( J:207033 )

• B-1a cells expressed significantly lower levels of BCR

decreased B-1a cell number ( J:207033 )

• B-1a cell population was dramatically reduced in the peritoneal caivty

abnormal B cell physiology ( J:207033 )

• impaired survival of B-1a cells

decreased B cell proliferation ( J:207033 )

• B-1a and B-1b cells show reduced proliferation

decreased IgG2b level ( J:207033 )

decreased IgM level ( J:207033 )

immune system

decreased plasma cell number ( J:207033 )

• greatly reduced frequency of IgM-secreting plasma cells

abnormal B-1a B cell morphology ( J:207033 )

• B-1a cells expressed significantly lower levels of BCR

decreased B-1a cell number ( J:207033 )

• B-1a cell population was dramatically reduced in the peritoneal caivty

abnormal B cell physiology ( J:207033 )

• impaired survival of B-1a cells

decreased B cell proliferation ( J:207033 )

• B-1a and B-1b cells show reduced proliferation

decreased IgG2b level ( J:207033 )

decreased IgM level ( J:207033 )

cellular

decreased B cell proliferation ( J:207033 )

• B-1a and B-1b cells show reduced proliferation