Phenotypes Associated with This Genotype

Genotype
MGI:6095197

• Allelic Composition: Emx1^tm1(cre)Krj/Emx1⁺; Ptpn11^tm6Bgn/Ptpn11⁺
• Genetic Background: B6.129S-Ptpn11^tm6Bgn Emx1^tm1(cre)Krj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:242312 )

• during auditory cued retrieval, mice show a reduced ability to discriminate conditional stimuli of 10-kHZ, 10 seconds with 20 seconds inter stimulus intervals (CS+) and conditional stimuli of 2.5-kHz, 10 seconds with 20 seconds inter stimulus intervals (CS-), with response to CS+ slightly reduced and to CS- somewhat increased

• however, mice exhibit normal levels of contextual fear memory

decreased exploration in new environment ( J:242312 )

• mice exhibit reduced exploratory behavior in the open field task, with a shorter run distance than controls

abnormal spatial learning ( J:242312 )

• in the Morris water maze, mice show a reduced path length during training and lower average speed resulting in similar escape latencies as controls, and reduced total distance traveled during probe trial 1, indicating reduced memory specificity

nervous system

abnormal hippocampus neuron morphology ( J:242312 )

• surface expression and trafficking of synaptic glutamate receptors is altered in hippocampal neurons, indicating possible hippocampal neuronal plasticity defects

• however, axonal outgrowth and dendritic arborization in cultured hippocampal neurons is similar to controls and synaptogenesis appears normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Noonan syndrome 1		DOID:0060578	OMIM:163950	J:242312