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Phenotypes Associated with This Genotype
Genotype
MGI:6093713
Allelic
Composition
Lifrtm1Imx/Lifrtm1Imx
Genetic
Background
B6;129S7-Lifrtm1Imx/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lifrtm1Imx mutation (1 available); any Lifr mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than the expected number (18.7% vs. 25%) of fetuses are seen at E18.5

growth/size/body
• small size at E18.5

endocrine/exocrine glands
• 100% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism

renal/urinary system
• 70% of fetuses show ureter and kidney anomalies at E18.5, with 10% having severe and 60% having milder anomalies
• various abnormalities are seen in fetuses, including mild or severe hydronephrosis, a dilated renal collecting system, blind-ending ureter, hydroureter, microcystically dilated tubules, and ureter ectopia
• 10% of fetuses exhibit renal dysplasia
• reduction of glomerular number per kidney volume and glomerular volume
• E15.5 kidney shows a reduction of comma shaped bodies, premature glomeruli, and all glomerular developmental stages per kidney section
• in a subset of mutants
• kidney size is reduced at E15.5
• in a subset of mutants
• nephron number is reduced at E15.5
• reduction of the proximal, medial and distal ureteric lumen at E18.5
• hypertrophy of the distal ureter wall
• thickness of the ureteric smooth muscle layer and the urothelium are increased
• in a subset of mutants
• in a subset of mutants
• 10% of E18.5 fetuses exhibit severe hydroureter

reproductive system
• 100% of fetuses show a ligamentous tethering of the testis to the dorsal aorta impairing testicular descent, indicating cryptorchidism

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
CAKUT DOID:0080205 OMIM:PS610805
J:242320


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory