Analysis Tools
neoplasm
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• onset of palpable mammary tumor formation is slightly delayed and growth of the primary tumor is reduced compared to control heterozygous Tgfb1i1tm1.1Cet Tg(MMTV-PyVT)634Mul mice
• tumor stroma contains fewer cancer-associated fibroblasts and reduced extracellular matrix deposition
• isolated cancer-associated fibroblasts are defective in stress fiber organization and exhibit reduced contractility
• more than 2-fold reduction in the number of proliferating cells in mammary tumors
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• mammary tumors exhibit fewer lung metastases than controls
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endocrine/exocrine glands
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• onset of palpable mammary tumor formation is slightly delayed and growth of the primary tumor is reduced compared to control heterozygous Tgfb1i1tm1.1Cet Tg(MMTV-PyVT)634Mul mice
• tumor stroma contains fewer cancer-associated fibroblasts and reduced extracellular matrix deposition
• isolated cancer-associated fibroblasts are defective in stress fiber organization and exhibit reduced contractility
• more than 2-fold reduction in the number of proliferating cells in mammary tumors
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integument
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• onset of palpable mammary tumor formation is slightly delayed and growth of the primary tumor is reduced compared to control heterozygous Tgfb1i1tm1.1Cet Tg(MMTV-PyVT)634Mul mice
• tumor stroma contains fewer cancer-associated fibroblasts and reduced extracellular matrix deposition
• isolated cancer-associated fibroblasts are defective in stress fiber organization and exhibit reduced contractility
• more than 2-fold reduction in the number of proliferating cells in mammary tumors
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