Phenotypes Associated with This Genotype

Genotype
MGI:6093452

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-CAMK2G*T287D,-EGFP)Whua}/Gt(ROSA)26Sor⁺; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:243363 )

• mice injected with azoxymethane (AOM) followed by DSS administration show increased distal colorectal cancer compared to controls, with higher average tumor number and increased number of small tumors and proportion of high-grade tumors

immune system

decreased susceptibility to induced colitis ( J:243363 )

• mice treated with dextran sodium sulfate (DSS) to induce colitis are protected from colitis-induced injury, showing suppression of weight loss and colonic shortening, decreased rectal bleeding rate, better epithelial crypt morphology, and higher proliferation rates and decreased cell death in colonic epithelial tissue compared to controls

neoplasm

increased incidence of tumors by chemical induction ( J:243363 )

• mice injected with azoxymethane (AOM) followed by DSS administration show increased distal colorectal cancer compared to controls, with higher average tumor number and increased number of small tumors and proportion of high-grade tumors

digestive/alimentary system

digestive/alimentary phenotype ( J:243363 )

N • mice exhibit normal gastrointestinal development and do not show signs of spontaneous colorectal tumor development up to 8 months of age

decreased susceptibility to induced colitis ( J:243363 )

• mice treated with dextran sodium sulfate (DSS) to induce colitis are protected from colitis-induced injury, showing suppression of weight loss and colonic shortening, decreased rectal bleeding rate, better epithelial crypt morphology, and higher proliferation rates and decreased cell death in colonic epithelial tissue compared to controls