Phenotypes Associated with This Genotype

Genotype
MGI:5925411

• Allelic Composition: Emp2^tm1.1Tac/Emp2^tm1.1Tac; Tg(Zp3-cre)93Knw/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal placenta vasculature ( J:243365 )

• placentas show reduced lectin and CD34 staining indicating changes in vasculature at E9.5 and E12.5

• placentas show differences in vessels organization

embryo

abnormal placenta morphology ( J:243365 )

• collagen deposition is up-regulated in placentas, with collagen around the yolk sac as in controls but also throughout the labyrinth at E16.5 which is not seen in controls

• increase in fibrin deposition in E16.5 placentas, throughout the decidua basalis and junctional zones

• increase in granulated leukocytes in E12.5 placenta

• marker analysis indicates signs of oxidative stress in the placenta

abnormal placenta vasculature ( J:243365 )

• placentas show reduced lectin and CD34 staining indicating changes in vasculature at E9.5 and E12.5

• placentas show differences in vessels organization

abnormal decidua basalis morphology ( J:243365 )

• fibrin deposition is increased throughout the decidua basalis

• uterine natural killer cells are increased in the decidual basalis of the placenta throughout gestation

increased uterine NK cell number ( J:243365 )

• uterine natural killer cells are increased in the decidual basalis of the placenta throughout gestation

endocrine/exocrine glands

increased uterine NK cell number ( J:243365 )

• uterine natural killer cells are increased in the decidual basalis of the placenta throughout gestation

hematopoietic system

increased leukocyte cell number ( J:243365 )

• increase in granulated leukocytes in E12.5 placenta

increased uterine NK cell number ( J:243365 )

• uterine natural killer cells are increased in the decidual basalis of the placenta throughout gestation

immune system

increased leukocyte cell number ( J:243365 )

• increase in granulated leukocytes in E12.5 placenta

increased uterine NK cell number ( J:243365 )

• uterine natural killer cells are increased in the decidual basalis of the placenta throughout gestation

reproductive system

abnormal decidua basalis morphology ( J:243365 )

• fibrin deposition is increased throughout the decidua basalis

• uterine natural killer cells are increased in the decidual basalis of the placenta throughout gestation

increased uterine NK cell number ( J:243365 )

• uterine natural killer cells are increased in the decidual basalis of the placenta throughout gestation

reduced fertility ( J:243365 )

• homozygous breeding pairs are slower to achieve pregnancy over time

decreased litter size ( J:243365 )

• reduction in litter size in homozygous females when the embryos carried are homozygous but not when the embryos are heterozygous

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
placental insufficiency		DOID:3891		J:243365