Emp2^tm1.1Tac
Targeted Allele Detail

Summary

• Symbol: Emp2^tm1.1Tac
• Name: epithelial membrane protein 2; targeted mutation 1.1, Taconic
• MGI ID: MGI:5925410
• Synonyms: Emp2^f
• Gene: Emp2 Location: Chr16:10099613-10131832 bp, - strand Genetic Position: Chr16, 5.54 cM
• Alliance: Emp2^tm1.1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243365
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was floxed by loxP sites via homologous recombination. Flp-mediated recombination removed a neo cassette. (J:243365)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Emp2 Mutation: 19 strains or lines available

References

• Original: J:243365 Williams CJ, et al., Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. J Pathol. 2017 Jun;242(2):246-259
• All: 3 reference(s)