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Phenotypes Associated with This Genotype
Genotype
MGI:5925369
Allelic
Composition
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(KRT14-cre)8Brn/0
Genetic
Background
involves: 129T2/SvEms * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Bjw mutation (1 available); any Ptch1 mutation (83 available)
Tg(KRT14-cre)8Brn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

growth/size/body
• severe growth deficiency such that mice do not progress beyond 49% of control weight, with differences first seen around P19

hematopoietic system

homeostasis/metabolism
• serum Igf1 levels are reduced
• however, serum growth hormone levels are normal

immune system

integument
• hyperproliferative lesions first develop in the skin around P19
• mice show rapid development basal cell carcinoma

neoplasm
• mice show rapid development basal cell carcinoma

reproductive system
• mice do not breed successfully


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/09/2018
MGI 6.11
The Jackson Laboratory