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Phenotypes Associated with This Genotype
Genotype
MGI:5912277
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Smarcd1tm1.1Jddl mutation (1 available); any Smarcd1 mutation (30 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:228944 )
• area of atherosclerotic lesions is reduced by about 53% compared to mice homozygous null for Apoe alone

homeostasis/metabolism
decreased circulating cholesterol level ( J:228944 )
• cholesterol levels are approximately 30% lower in Western diet fed mice compared to diet matched controls
abnormal bile salt homeostasis ( J:228944 )
• expression analysis indicates bile acid metabolism is reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory