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Phenotypes Associated with This Genotype
Genotype
MGI:5912245
Allelic
Composition		 Ace2tm1Pngr/Y
Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Pngr mutation (1 available); any Ace2 mutation (54 available)
Pik3cgtm1Pngr mutation (0 available); any Pik3cg mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased cardiac muscle contractility ( J:124548 )
• increase in basal myocardial contractility
• mice exhibit a partial reversal of myocardial hypertrophy, prevention of neutrophil infiltration into myocardial tissue, and prevention of systolic function deterioration

muscle
increased cardiac muscle contractility ( J:124548 )
• increase in basal myocardial contractility
• mice exhibit a partial reversal of myocardial hypertrophy, prevention of neutrophil infiltration into myocardial tissue, and prevention of systolic function deterioration

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory