Phenotypes Associated with This Genotype

Genotype
MGI:5911667

• Allelic Composition: Mir146^tm1.1Bal/Mir146^tm1.1Bal; Tifab^tm1.1Dsta/Tifab^tm1.1Dsta
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased neutrophil cell number ( J:229024 )

• decrease in neutrophil numbers at 4 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice

• decrease is greater than in either single homozygote

decreased lymphocyte cell number ( J:229024 )

• decrease in lymphocyte numbers at 4 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice

• decrease is greater than in either single homozygote

abnormal hematopoietic stem cell morphology ( J:229024 )

• total colony formation is increased in vitro and progenitors show an additive increase in CFU-G colony formation compared to either single homozygote

immune system

decreased neutrophil cell number ( J:229024 )

• decrease in neutrophil numbers at 4 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice

• decrease is greater than in either single homozygote

decreased lymphocyte cell number ( J:229024 )

• decrease in lymphocyte numbers at 4 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice

• decrease is greater than in either single homozygote