Phenotypes for Bcl10 Cd19 Gt(ROSA)26Sor MGI:5908454 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bcl10^tm1Mak/Bcl10^tm1Mak Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl10^tm1Mak mutation (1 available); any Bcl10 mutation (16 available)
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld} mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:228288 )

N	• absence of Bcl10 expression rescues the early lethality seen in mutant mice wild-type for Bcl10

immune system

immune system phenotype ( J:228288 )

N	• absence of Bcl10 expression rescues the pathological B-cell activation, differentiation, and malignant proliferation seen in mutant mice wild-type for Bcl10

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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