Phenotypes Associated with This Genotype

Genotype
MGI:5903780

• Allelic Composition: Igk^tm1Dhu/Igk^tm1Dhu; Tg(H2-Ea-HA)HACIIAjca/0; Tg(TcraS106-1,TcrbS106-1)TS1SWAjca/0
• Genetic Background: C.Cg-Igk^tm1Dhu Tg(H2-Ea-HA)HACIIAjca Tg(TcraS106-1,TcrbS106-1)TS1SWAjca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

absent B cells ( J:209872 )

abnormal CD4-positive, alpha beta T cell morphology ( J:209872 )

• decrease in the percentages of IL-17- and IFN-gamma-secreting Valpha8.3+VBeta10+ CD4+T cells in the joint-draining lymph nodes of nonarthritic mice

• in mice that develop arthritis despite absence of B cells, the frequencies of IFN-gamma-secreting Valpha8.3+VBeta10+ CD4+T are reduced relative to arthritic double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice, but the frequencies of IL-17-secreting Valpha8.3+VBeta10+CD4+ T cells are not

• nonarthritic mice show lower frequencies of clonotypic, but not of total, IFN-gamma-, and IL-17 producing CD4+ T cells than nonarthritic double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

increased CD4-positive, alpha-beta T cell number ( J:209872 )

• percentage of CD4+ T cells is increased, however the number of CD4+ T cells expressing the Vslpha8.3+Vbeta10+ clonotypic TCR does not differ from double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

abnormal spleen morphology ( J:209872 )

• decrease in the overall cellularity of spleens

immune system

absent B cells ( J:209872 )

abnormal CD4-positive, alpha beta T cell morphology ( J:209872 )

• decrease in the percentages of IL-17- and IFN-gamma-secreting Valpha8.3+VBeta10+ CD4+T cells in the joint-draining lymph nodes of nonarthritic mice

• in mice that develop arthritis despite absence of B cells, the frequencies of IFN-gamma-secreting Valpha8.3+VBeta10+ CD4+T are reduced relative to arthritic double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice, but the frequencies of IL-17-secreting Valpha8.3+VBeta10+CD4+ T cells are not

• nonarthritic mice show lower frequencies of clonotypic, but not of total, IFN-gamma-, and IL-17 producing CD4+ T cells than nonarthritic double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

increased CD4-positive, alpha-beta T cell number ( J:209872 )

• percentage of CD4+ T cells is increased, however the number of CD4+ T cells expressing the Vslpha8.3+Vbeta10+ clonotypic TCR does not differ from double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice

abnormal spleen morphology ( J:209872 )

• decrease in the overall cellularity of spleens

abnormal lymph node morphology ( J:209872 )

• decrease in the overall cellularity of the joint-draining lymph nodes

decreased susceptibility to autoimmune disorder ( J:209872 )

• mice exhibit decreased arthritis development compared to double Tg(Tcra/Tcrb)#Ajca/0 Tg(H2-Ea-HA)#Ajca/0 transgenic mice