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Phenotypes Associated with This Genotype
Genotype
MGI:5902497
Allelic
Composition		 B3gnt6tm1Lx/B3gnt6tm1Lx
C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B3gnt6tm1Lx mutation (0 available); any B3gnt6 mutation (13 available)
C1galt1tm1.1Rpmc mutation (1 available); any C1galt1 mutation (24 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased duodenum glandular epithelium tumor incidence ( J:239765 )
• mice injected with tamoxifen at 1.5- to 4-months of age develop spontaneous duodenal tumors between 12 and 24 months of age, exhibiting mostly proliferative epithelium
increased duodenum adenocarcinoma incidence ( J:239765 )
• tumors in tamoxifen-injected mice are aggressive and advance to adenocarcinoma

neoplasm
increased duodenum glandular epithelium tumor incidence ( J:239765 )
• mice injected with tamoxifen at 1.5- to 4-months of age develop spontaneous duodenal tumors between 12 and 24 months of age, exhibiting mostly proliferative epithelium
increased duodenum adenocarcinoma incidence ( J:239765 )
• tumors in tamoxifen-injected mice are aggressive and advance to adenocarcinoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
duodenum cancer DOID:10021 J:23965

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory