Phenotypes Associated with This Genotype

Genotype
MGI:5902066

• Allelic Composition: Del(XMagea1-Magea6)1Nju/Y; Tg(EIIa-cre)C5379Lmgd/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oligozoospermia ( J:240206 )

♂ • overall sperm count normal at P30 and 5 months

♂ • decrease in the testicular sperm reserve at 2 months

increased cellular sensitivity to DNA damaging agents ( J:240206 )

♂ • increased proportions of apoptotic and dead spermatocytes in the seminiferous tubules 24h after injection with DNA-damaging agent N-ethyl-N-nitrosourea (ENU) at 3 months

♂ • higher levels of Trp53 protein in the testes 3 hours after ENU administration

♂ • higher level of Ser15-phosphorylation of Trp53 in the testes 6 hours after ENU treatment

♂ • increased level of apoptosis marker Bax in testes 6 hours after ENU treatment

increased male germ cell apoptosis ( J:240206 )

♂ • increased apoptosis in spermatocytes at P12

endocrine/exocrine glands

small seminiferous tubules ( J:240206 )

♂ • reduction in the area, diameter and perimeter of the seminiferous tubules at 3 months

decreased testis weight ( J:240206 )

♂ • P30 and earlier

♂ • average testicular mass to body mass ratio was 16.6% lower from 2 months

reproductive system

oligozoospermia ( J:240206 )

♂ • overall sperm count normal at P30 and 5 months

♂ • decrease in the testicular sperm reserve at 2 months

increased male germ cell apoptosis ( J:240206 )

♂ • increased apoptosis in spermatocytes at P12

small seminiferous tubules ( J:240206 )

♂ • reduction in the area, diameter and perimeter of the seminiferous tubules at 3 months

decreased testis weight ( J:240206 )

♂ • P30 and earlier

♂ • average testicular mass to body mass ratio was 16.6% lower from 2 months