Phenotypes Associated with This Genotype

Genotype
MGI:5901907

• Allelic Composition: Pgr^tm2(cre)Lyd/Pgr⁺; Ror1^tm1.1Meg/Ror1^tm1.1Meg; Ror2^tm1.1Meg/Ror2^tm1.1Meg
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal maternal decidual layer morphology ( J:233595 )

♀ • abnormal primary decidual zone (PDZ) development at 6 dpc

♀ • PDZ was absent in some implantation sites with the embryo entrapped within the intact epithelium at 6 dpc

abnormal embryo attachment ( J:233595 )

♀ • uteri either failed to show or had very weak endometrial vascular permeability at the site of blastocyst attachment at 5 dpc

♀ • unattached blastocysts were recovered from uteri at 5 dpc

♀ • defects in crypt formation

♀ • some blastocysts situated within the primary lumen

reduced female fertility ( J:233595 )

♀ • only 29% of plug-positive females produce a (small) litter

♀ • high resorption rates on 12 dpc

decreased litter size ( J:233595 )

♀ • in the few fertile mice

embryo

abnormal maternal decidual layer morphology ( J:233595 )

♀ • abnormal primary decidual zone (PDZ) development at 6 dpc

♀ • PDZ was absent in some implantation sites with the embryo entrapped within the intact epithelium at 6 dpc