Phenotypes for Apc Tg(Pdx1-cre)6Tuv MGI:5898452 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apc^tm2Rak/Apc^tm2Rak Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129/Sv * C57BL/6J * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm2Rak mutation (0 available); any Apc mutation (151 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:234310 )

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:234310 )

decreased pancreatic islet number ( J:234310 )

abnormal pancreas development ( J:234310 )

• maturation of the prenatal pancreas is disrupted

digestive/alimentary system

abnormal intestine development ( J:234310 )

• altered gastrointestinal development

duodenal atresia ( J:234310 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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