Phenotypes Associated with This Genotype

Genotype
MGI:5897855

• Allelic Composition: Braf^tm1Mmcm/Braf⁺; Tg(TPO-cre/ERT2)1139Tyj/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:208854 )

• mice administered tamoxifen develop papillary thyroid carcinomas

• tumors show both papillary growth morphology and nuclear features of papillary thyroid carcinoma

• even with very long latency, extrathyroidal invasion is not seen and cervical lymph node metastases are not seen

neoplasm

increased thyroid carcinoma incidence ( J:208854 )

• mice administered tamoxifen develop papillary thyroid carcinomas

• tumors show both papillary growth morphology and nuclear features of papillary thyroid carcinoma

• even with very long latency, extrathyroidal invasion is not seen and cervical lymph node metastases are not seen

respiratory system

respiratory failure ( J:208854 )

• tamoxifen treated mice generally succumb to respiratory compromise due to tracheal compression by large noninvasive tumors