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Phenotypes Associated with This Genotype
Genotype
MGI:5897816
Allelic
Composition		 Mob1atm1.1Asuz/Mob1atm1.1Asuz
Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mob1atm1.1Asuz mutation (0 available); any Mob1a mutation (15 available)
Mob1bGt(CC0690)Wtsi mutation (0 available); any Mob1b mutation (19 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Tgfbr2tm1Roes mutation (2 available); any Tgfbr2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal cholangiocyte morphology ( J:228499 )
• increased immature cholangiocyte-like and oval cells but not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice
increased liver weight ( J:228499 )
• not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice
liver fibrosis ( J:228499 )
• not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice

endocrine/exocrine glands
abnormal cholangiocyte morphology ( J:228499 )
• increased immature cholangiocyte-like and oval cells but not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice

growth/size/body
increased liver weight ( J:228499 )
• not as much as in Mob1atm1.1Asuz/Mob1atm1.1Asuz Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi Tg(Alb-cre)21Mgn mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory