Phenotypes Associated with This Genotype

Genotype
MGI:5897781

• Allelic Composition: Rcor2^{tm1c(EUCOMM)Wtsi}/Rcor2^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain size ( J:235702 )

• at E13.5 and E15.5

abnormal cerebral cortex morphology ( J:235702 )

• abnormalities in lamination at E15.5

decreased cerebral cortex pyramidal cell number ( J:235702 )

• expression analysis indicates a dramatic decrease at E15.5

thin cerebral cortex ( J:235702 )

• at E15.5

decreased neuronal precursor cell number ( J:235702 )

• at E15.5

abnormal neuron physiology ( J:235702 )

• cortical neural progenitor cells appear to exit the cell cycle earlier compared to controls

decreased neuronal precursor proliferation ( J:235702 )

• cortical neural progenitor cells form smaller neurospheres in culture

• inhibition of SHH with Cyclopamine increases neurosphere size

cellular

abnormal cell cycle ( J:235702 )

• cortical neural progenitor cells appear to exit the cell cycle earlier compared to controls

decreased neuronal precursor proliferation ( J:235702 )

• cortical neural progenitor cells form smaller neurospheres in culture

• inhibition of SHH with Cyclopamine increases neurosphere size