Phenotypes Associated with This Genotype

Genotype
MGI:5897405

• Allelic Composition: Tg(Myh6-Map2k1*)1Jmol/0; Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0; Tg(Myh6-tTA)55Rbns/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

thick interventricular septum ( J:234490 )

• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol and wild-type mice

increased heart weight ( J:234490 )

• compared with wild-type mice

abnormal heart left ventricle morphology ( J:234490 )

• left ventricular wall thickness is increased compared with wild-type and Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

• however, left ventricle size is rescued compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

increased cardiac muscle contractility ( J:234490 )

• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

muscle

increased cardiac muscle contractility ( J:234490 )

• compared to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

growth/size/body

increased heart weight ( J:234490 )

• compared with wild-type mice