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Phenotypes Associated with This Genotype
Genotype
MGI:5897396
Allelic
Composition		 Plntm1Egk/Plntm1Egk
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation (7 available); any Pln mutation (16 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal interventricular septum morphology ( J:234490 )
• improved compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased heart weight ( J:234490 )
• more severe than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
increased heart left ventricle size ( J:234490 )
• as in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
abnormal myocardial fiber physiology ( J:234490 )
• faster mechanical relaxation of myocyte contraction compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol
abnormal myocardial fiber calcium currents ( J:234490 )
• faster Ca2+ transient decay time compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol

growth/size/body
increased heart weight ( J:234490 )
• more severe than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory