Phenotypes Associated with This Genotype

Genotype
MGI:5897383

• Allelic Composition: Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0; Tg(Myh6-tTA)55Rbns/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:234490 )

• some mice die by 4 months of age with no mice surviving beyond 8 months

cardiovascular system

thin interventricular septum ( J:234490 )

• at baseline

increased heart weight ( J:234490 )

• at baseline

increased heart left ventricle size ( J:234490 )

• at baseline

decreased cardiac muscle contractility ( J:234490 )

• at baseline

increased cardiac muscle relaxation ( J:234490 )

• at baseline

abnormal myocardial fiber physiology ( J:234490 )

• reduced time at elevated tension with a set amount of Ca+2

• increased diastolic Ca2+ concentration

muscle

decreased cardiac muscle contractility ( J:234490 )

• at baseline

increased cardiac muscle relaxation ( J:234490 )

• at baseline

abnormal sarcomere morphology ( J:234490 )

• elongated and increased length-to-width ratios at baseline

growth/size/body

increased heart weight ( J:234490 )

• at baseline