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Phenotypes Associated with This Genotype
Genotype
MGI:5897183
Allelic
Composition
Cd163tm1(KOMP)Vlcg/Cd163tm1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6NTac
Cell Lines 10143B-A3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd163tm1(KOMP)Vlcg mutation (1 available); any Cd163 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• in a house dust mite-challenge, mice exhibit increased eosinophil in total bronchoalveolar lavage fluid, increased peri-bronchial inflammatory cell infiltrates, and increased airway remodeling evidenced by increased mucous cell metaplasia compared with wild-type mice
• however, mice exhibit normal numbers of macrophages, lymphocytes and neutrophils and treatment with anti-CCL24 antibodies exhibit a phenotypic rescue
• mucous cell metaplasia in a house dust mite-challenge

immune system
• in a house dust mite-challenge, mice exhibit increased eosinophil in total bronchoalveolar lavage fluid, increased peri-bronchial inflammatory cell infiltrates, and increased airway remodeling evidenced by increased mucous cell metaplasia compared with wild-type mice
• however, mice exhibit normal numbers of macrophages, lymphocytes and neutrophils and treatment with anti-CCL24 antibodies exhibit a phenotypic rescue


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory