respiratory system
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• in a house dust mite-challenge, mice exhibit increased eosinophil in total bronchoalveolar lavage fluid, increased peri-bronchial inflammatory cell infiltrates, and increased airway remodeling evidenced by increased mucous cell metaplasia compared with wild-type mice
• however, mice exhibit normal numbers of macrophages, lymphocytes and neutrophils and treatment with anti-CCL24 antibodies exhibit a phenotypic rescue
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• mucous cell metaplasia in a house dust mite-challenge
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immune system
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• in a house dust mite-challenge, mice exhibit increased eosinophil in total bronchoalveolar lavage fluid, increased peri-bronchial inflammatory cell infiltrates, and increased airway remodeling evidenced by increased mucous cell metaplasia compared with wild-type mice
• however, mice exhibit normal numbers of macrophages, lymphocytes and neutrophils and treatment with anti-CCL24 antibodies exhibit a phenotypic rescue
|


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