About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5896991
Allelic
Composition
Ednrbtm1Nrd/Ednrbtm1Nrd
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbtm1Nrd mutation (1 available); any Ednrb mutation (74 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (2 available); any Gt(ROSA)26Sor mutation (393 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mice develop intestinal inflammation in both the proximal and mid-colon by P26-29
• however, no inflammation is seen at earlier time points on in the small intestine

hematopoietic system
• mature B-lymphocytes are reduced in Peyers patches and are enriched in the spleen
• the proportion of total B-lymphocytes in Peyers patches is decreased to about 80% of levels seen in controls, indicating a 3.6-fold reduction in the number of B cells
• mice show a decrease of B-lymphocytes in the germinal centers of spleens and a decrease of B-lymphocytes within the marginal zones
• however, no differences in pre/pro-B lymphocyte and mature B lymphocyte populations at P21 in the bone marrow
• mice show a decrease of B-lymphocytes in the germinal centers of spleens
• mice exhibit splenic lymphopenia
• mice show a decrease of B-lymphocytes within the marginal zones
• spleens in P21-P24 mice are smaller in size
• spleens weigh less than those of controls as a proportion of the total body weight
• decrease in the proportion of total (B220+) B-lymphocytes and in the numbers of total B lymphocytes in spleens
• increase in the proportion of mature B-lymphocytes in the spleen, although numbers are decreased
• secretory IgA is decreased in the small intestine
• however, no differences in secretory IgA are seen in the nasal airway lavage or bronchoalveolar lavage and no differences in small bowel luminal IgM levels are seen

immune system
• mice develop intestinal inflammation in both the proximal and mid-colon by P26-29
• however, no inflammation is seen at earlier time points on in the small intestine
• mature B-lymphocytes are reduced in Peyers patches and are enriched in the spleen
• the proportion of total B-lymphocytes in Peyers patches is decreased to about 80% of levels seen in controls, indicating a 3.6-fold reduction in the number of B cells
• mice show a decrease of B-lymphocytes in the germinal centers of spleens and a decrease of B-lymphocytes within the marginal zones
• however, no differences in pre/pro-B lymphocyte and mature B lymphocyte populations at P21 in the bone marrow
• mice show a decrease of B-lymphocytes in the germinal centers of spleens
• mice exhibit splenic lymphopenia
• mice show a decrease of B-lymphocytes within the marginal zones
• spleens in P21-P24 mice are smaller in size
• spleens weigh less than those of controls as a proportion of the total body weight
• decrease in the proportion of total (B220+) B-lymphocytes and in the numbers of total B lymphocytes in spleens
• increase in the proportion of mature B-lymphocytes in the spleen, although numbers are decreased
• secretory IgA is decreased in the small intestine
• however, no differences in secretory IgA are seen in the nasal airway lavage or bronchoalveolar lavage and no differences in small bowel luminal IgM levels are seen
• Peyers patches are hypocellular and exhibit B-cell lymphopenia
• Peyers patches are small in size in P21-P24 mice but have normal architecture


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/14/2017
MGI 6.11
The Jackson Laboratory